Genes, autoimmune disease and Sz

Alterations in immune function and reactivity in schizophrenia (SZ) and mood disorders have been found and extensively reviewed [1,2,3]. Reports of immune dysfunction in transcriptomic and proteomic studies of brain tissue have been reported primarily in SZ (reviewed in [4,5]). The majority of studies have analyzed antibodies, cytokines, and blood cell types, and indexed these markers as either an indicator of pro- or anti-inflammatory reactions or secondary responses. These studies have shown a remarkable diversity of findings and some gains in understanding relationships between psychopathology and immune function