FKBP5 and schizophrenia (Matosin et al., 2023)

Published on 2 Feb 2023:

# Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex

A quote:

Here, we performed an extensive, large-scale postmortem study (n = 1024) of FKBP5/ 1, examining neocortical areas (BA9, BA11 and ventral BA24/BA24a) derived from subjects that lived with schizophrenia, major depression or bipolar disorder. […] We identified consistently heightened FKBP5/ 1 levels in psychopathology and with age, but not genotype, with these effects strongest in schizophrenia.

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See also:

In PDF: The role of the interaction between the FKBP5 gene and stressful life events in the pathophysiology of schizophrenia: A narrative review (Stramecki et al., 2020)

In Archives of Psychiatry and Psychotherapy, 2020; 3: 7–16