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I hope I get a pdoc and talk about Cobenfy.
Seems promising.
But Invega has been so good to me, I don’t know.
Your doctor will know what is best. From what I read, Cobenfy does not cause sedation, and regarding weight gain. It does not increase weight but it does not reduce it drastically either. At least that is what I read, on average people lost 2.6 kilos after taking it for 1 year. They did not return to their original weight, that is another of my doubts.
Welcome to the forum
To be fair, a lot of szs are using food as an emotional crutch.
One cannot do drink or drugs any more so food becomes a pleasure principle.
Then the more they eat this stuff the more addicted to fast food they become ; craving it like any other drug.
Emotional eating is a thing.
I eat very little and spend my time hungry a lot of the time and manage to keep my weight under 72kg and i am on paliperidone and risperidone.
It is possible to do it, but it takes a lot of inner strength and will power.
Given a chance to take this drug I’d welcome it and iI imagine I’ll be ‘allowed’ to eat more due to it.
In my case, the weight gain is indefinite. I keep gaining weight. I weighed 95 kg until I had to stop taking the antipsychotic.
Thanks for the welcomes!
And I hear you. I don’t eat breakfast. Tiny tiny lunch. And my dinner is within normal portions. And I’m unable to lose the initial weight I gained. Olanzapine is rough but it does work. I didn’t have this weight problem on aripiprazole or paliperidone (the other two I tried before olanzapine).
It’s disheartening to hear that on Cobenfy people don’t return to their previous weight (before meds like olanzapine).
I will have to talk to my psych doctor.
Welcome to the forum. I like your profile picture. 
wow that sucks. Hope KarXT works for you. 
MeH: On my current medication, I noticed that negative symptons improved. when they lowered the dose. Other then that you just have to go out and do stuff.
‘‘Other drug developers are also looking to exploit the muscarinic pathway for the treatment of schizophrenia. According to GlobalData’s drug database, there are seven pipeline products in clinical development (Phase I-III) for schizophrenia that have muscarinic acetylcholine receptors as a molecular target.’’
They do lose weight, if you read the clinical trials, you will see that people lost a lot of weight if they were obese while taking the medicine
It seems that Cobenfy has only been approved as a monotherapy for sz so far; it is currently awaiting to be studied as an adjunctive treatment in a phase 3 trial, named ARISE.
Hopefully it will be approved as an adjunctive treatment, which will be desirable for me, since I seem to always need to be on at least a low dose of a second generation antipsychotic.
Researchers are now working to add muscarinic agonists to existing dopaminergic drug regimens, in the hopes of efficacy gains for the 75–80% of patients who currently have inadequately managed symptoms of schizophrenia. A phase III study of adjunctive KarXT is ongoing, with a top-line readout anticipated early in 2025. “That trial is going to be very important,” said Steve Paul, a psychiatrist at Washington University and a former CEO of Karuna.
Source: FDA approves first schizophrenia drug with new mechanism of action since 1950s
I’ll take nausea over diabetes. I’m gonna see if I can try this when it’s an option.
Here is the official page of the drug Cobenfy
I hope people who will try it will write reviews. The most interesting reviews will be those who have tried the current meds and transitioned.
Probably jumping the gun, but I looked on GoodRX.com for Cobenfy. The default listing was for 30 capsules, which is 15 day supply. Entering a custom amount of 60 capsules, for 30 days, the price was about $1896 at Target and CVS only. I do not know if they actually have it available yet.
https://www.goodrx.com/cobenfy
https://www.goodrx.com/cobenfy?form=capsule&dosage=125mg-30mg&quantity=60&label_override=cobenfy
When I was in the US, Latuda was 40 dollars a 40 mgs pill, and I needed 4 pills a day— the medicaid covered it, at the pdoc’s request of course. You can say that nothing works for you-- what option would they have but to grant you permission to take Cobenfy?
I think they set the price of Cobenfy too high because they know that the government and social security agencies will have to cover the cost of the medication, since the side effects of current antipsychotics are too many and can lead to death.
I am thinking of going to court because I cannot tolerate current antipsychotics, neither mentally nor physically.