Your doctor will know what is best. From what I read, Cobenfy does not cause sedation, and regarding weight gain. It does not increase weight but it does not reduce it drastically either. At least that is what I read, on average people lost 2.6 kilos after taking it for 1 year. They did not return to their original weight, that is another of my doubts.
And I hear you. I don’t eat breakfast. Tiny tiny lunch. And my dinner is within normal portions. And I’m unable to lose the initial weight I gained. Olanzapine is rough but it does work. I didn’t have this weight problem on aripiprazole or paliperidone (the other two I tried before olanzapine).
It’s disheartening to hear that on Cobenfy people don’t return to their previous weight (before meds like olanzapine).
MeH: On my current medication, I noticed that negative symptons improved. when they lowered the dose. Other then that you just have to go out and do stuff.
‘‘Other drug developers are also looking to exploit the muscarinic pathway for the treatment of schizophrenia. According to GlobalData’s drug database, there are seven pipeline products in clinical development (Phase I-III) for schizophrenia that have muscarinic acetylcholine receptors as a molecular target.’’
It seems that Cobenfy has only been approved as a monotherapy for sz so far; it is currently awaiting to be studied as an adjunctive treatment in a phase 3 trial, named ARISE.
Hopefully it will be approved as an adjunctive treatment, which will be desirable for me, since I seem to always need to be on at least a low dose of a second generation antipsychotic.
Researchers are now working to add muscarinic agonists to existing dopaminergic drug regimens, in the hopes of efficacy gains for the 75–80% of patients who currently have inadequately managed symptoms of schizophrenia. A phase III study of adjunctive KarXT is ongoing, with a top-line readout anticipated early in 2025. “That trial is going to be very important,” said Steve Paul, a psychiatrist at Washington University and a former CEO of Karuna.
When I was in the US, Latuda was 40 dollars a 40 mgs pill, and I needed 4 pills a day— the medicaid covered it, at the pdoc’s request of course. You can say that nothing works for you-- what option would they have but to grant you permission to take Cobenfy?
I think they set the price of Cobenfy too high because they know that the government and social security agencies will have to cover the cost of the medication, since the side effects of current antipsychotics are too many and can lead to death.
I am thinking of going to court because I cannot tolerate current antipsychotics, neither mentally nor physically.