pardon me, what does this mean?
this is a new target for treatments, elevated dopamine synthesis capacity. they think psychosis in general not just sz might be connected to this, as they tested psychotic bipolar patients. if good treatments can be formulated which treat this form of dysfunction they might help us. otherwise it is helpful to know dopamine synthesis capacity might be related to psychosis.
It’s interesting, but I don’t understand why it’s new. I mean, didn’t we already know that dopamine is elevated? Dopamine synthesis means the capacity to create dopamine. Maybe it’s the striatum vs some other part of the brain? And people with bipolar psychosis are already being treated with D2 blocking APs. So I’m confused about what’s new or unexpected about this.
if a treatment adressed the underlying issue, the predisposition or tendency to create more dopamine rather than blocking the dopamine after it has been created, then that might be a more seamless treatment i think.
Perhaps the diff is blocking the dopamine from being created as opposed to blocking how effective it is? I don’t know exactly how antipsychotics work… Also want to know what can be done for the negative effects of sz. No headway has been made on that front yet, where as for the positive ones, the antipsychotics (of one sort or other) take care of it for most people.
Ah I see, yes that does sound like a better approach.
I think this dr is working on it too:
His drug candidate is supposed to prevent dopamine from being released. It’s supposed to be in phase 1 this year.
I do hope they can get these type of drugs out to us soon!