R Ayesa-Arriola, V OrtĂz-GarcĂa de la Foz, O MartĂnez-GarcĂa, E SetiĂ©n-Suero, ML RamĂrez, P Suárez-Pinilla, J Mayoral Van Son, J Vázqez-Bourgon, M Juncal-Ruiz, M GĂłmez-Revuelta, D Tordesilas-GutiĂ©rrez and B Crespo-Facorro,
Psychological medicine, Nov 2019 18
The aim of the current study was to examine the heterogeneity of functional outcomes in first episode psychosis (FEP) patients and related clinical, neurocognitive and sociodemographic factors using a cluster analytic approach.A large sample of FEP patients (N = 209) was functionally reassessed 10 years after the first contact with an early intervention service. Multiple baseline, 3-year and 10-year follow-up variables were explored.The cluster analysis emphasized the existence of six independent clusters of functioning: one cluster was normal overall (42.16%), two clusters showed moderate interpersonal (9.63%) or instrumental (12.65%) deficits, two clusters showed more severe interpersonal (12.05%) or interpersonal and instrumental (13.85%) deficits and there was a significantly overall impaired cluster (9.63%). Cluster comparisons showed that several baseline and follow-up factors were differentially involved in functional outcomes.The current study demonstrated that distinct clusters of functioning in FEP patients can be identified. The fact that a variety of profiles was observed contributes to a better understanding of the nature of the heterogeneity characterizing FEP patients and has clinical implications for developing individualized treatment plans.