Association between schizophrenia and an autoimmune bullous skin disease-pemphigus: a population-based large-scale study

anon79999497 · September 26, 2017, 10:54am

ncbi.nlm.nih.gov

Association between schizophrenia and an autoimmune bullous skin disease-pemphigus: a population-based large-scale study.

K Kridin, S Zelber-Sagi, D Comaneshter and AD Cohen, Epidemiology and psychiatric sciences, Sep 25 2017

Immunological hypotheses have become increasingly prominent suggesting that autoimmunity may be involved in the pathogenesis of schizophrenia. Schizophrenia was found to be associated with a wide range of autoimmune diseases. However, the association between pemphigus and schizophrenia has not been established yet. We aimed to estimate the association between pemphigus and schizophrenia using a large-scale real-life computerised database.This study was conducted as a cross-sectional study utilising the database of Clalit Health Services. The proportion of schizophrenia was compared between patients diagnosed with pemphigus and age-, gender- and ethnicity-matched control subjects. Univariate analysis was performed using χ 2 and Student's t-test and a multivariate analysis was performed using a logistic regression model.A total of 1985 pemphigus patients and 9874 controls were included in the study. The prevalence of schizophrenia was greater in patients with pemphigus as compared to the control group (2.0% v. 1.3%, respectively; p = 0.019). In a multivariate analysis, pemphigus was significantly associated with schizophrenia (OR, 1.5; 95% CI, 1.1-2.2). The association was more prominent among females, patients older than 60 years, and Jews.Pemphigus is significantly associated with schizophrenia. Physicians treating patients with pemphigus should be aware of this possible association. Patients with pemphigus should be carefully assessed for comorbid schizophrenia and be treated appropriately.

Orbeezlight · September 26, 2017, 1:09pm

This is interesting as it does feel like inflamation or allergy severe symotoms, even poison. Immune system malfunction

Hedgehog · September 26, 2017, 2:16pm

I don’t think I understand that goal of linking sz with a specific auto-immune condition. Isn’t it enough to say that it’s linked to having auto-immune issues in general? Lupus runs in my family, and my son had Kawasaki Disease when he was little. Just hearing that generally a person with sz will also be prone to auto-immune disorders is interesting to me. Maybe I don’t understand the significance of being so specific.

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Association between schizophrenia and an autoimmune bullous skin disease-pemphigus: a population-based large-scale study

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