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" tudy Conclusions
The authors concluded that clozapine was associated with almost threefold increased odds (versus haloperidol) of new-onset OCD inpatients with schizophrenia, with no significant difference in risk for other antipsychotics. Strengths of the study include the population-based representative sample. Study limitations include the inability to assess the frequency of subthreshold OCS, which are more common than OCD and may require clinical attention. Data on other potential risk factors, such as genetics/family history of OCD and severity of psychotic symptoms, were not available.
The Bottom Line
There is reliable evidence for the risk of OCD associated with commonly prescribed antipsychotics, particularly clozapine (and within the first 2 years of treatment)."