Antipsychotic Polypharmacy and Corrected QT Interval: A Systematic Review

I know many people here are concerned about their heart’s QR interval and the impact that medications can have on the heart in general. Here is a new research summary on the topic:


Currently available evidence fails to confirm that antipsychotic polypharmacy worsens QTc prolongation in general, although the evidence is scarce and inconsistent. Clinicians are advised to remain conservative in resorting to antipsychotic polypharmacy, as a combination of some QTc-prolongation liable antipsychotics may further prolong QTc interval, and efficacy supporting the clinical benefits of antipsychotic polypharmacy is equivocal, at best.


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