Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial

CONCLUSION:

Although adjunctive citalopram did not improve negative symptoms overall, there was evidence of some positive effect on avolition/amotivation, recognised as a critical barrier to psychosocial rehabilitation and achieving better social and community functional outcomes. Comprehensive assessment of side-effect burden did not identify any serious safety or tolerability issues.

The addition of citalopram as a long-term prescribing strategy for the treatment of negative symptoms may merit further investigation in larger studies.

More information on Citalopram:

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A friend who has deficit schizophrenia (like me) has been taking Escitalopram for a year and she tells me negative symptoms are lighter now. It’s worth a try anyway.

[quote=“Andrey, post:2, topic:47722”]
Escitalopram
[/quote]i was on Escitalopram before…
now i quit it…
thought this time i won’t go off med…
my sleep is seriously halted…

What do you mean by “halted” ? You can’t sleep ?
I sleep 12 hours !!

I think with all these things you will get some people who do well on a treatment when overall the results are negative, or some that will do badly although the overall results are positive.
The main aim though is to help as many people as possible and that plays into what treatments are recommended/utilised to help treat a condition. If a treatment doesn’t help that many people it’s unlikely to be pursued much further.
In the case of citalopram it seems to be potentially beneficial with certain aspects of negative symptoms therefore worth pursuing despite the overall negative result.

i hardly sleep for 5 hour…
i shouldn’t have skipped medicine…
i am rearranging appointment with pdoc this week…
i used to take zyperia 7.5mg…i fear diabetes out of it…cuz…
my mom and dad they both have diabetes…so
i am on high risk zone… and …
my positive symptoms are manageable while negative and cognitive symptoms are dreadful…
so i am reluctant to take medicine…but…
i don’t want to suffer any more…
@Andrey hope ur doing fine…
thanks…
take care…:pray:

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