Adding an antidepressant was associated with a lower risk of psychiatric hospitalization and emergency department visits, whereas adding a benzodiazepine was associated with a higher risk of these outcomes

Conclusions and Relevance In the treatment of schizophrenia, initiating adjunctive treatment with an antidepressant was associated with reduced risk of psychiatric hospitalization and ED visits compared with initiating use of alternative psychotropic medications. Associations of benzodiazepines and mood stabilizers with poorer outcomes warrant clinical caution and further investigation.

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Well, there’s antidepressants, and there’s antidepressants.

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