Yokukansas

andrea866 · May 24, 2015, 9:56am

some of you have had experience with yokukansan? is really effective on positive and negative symptoms? I will try yokukansan to my sister who is suffering from schizophrenia and will bring you here on site the results …
thank you all …
help each of us to overcome this terrible disease …

Jayster · May 24, 2015, 3:32pm

I’m suspicious of herbs. For one thing, each different batch of the same herb is going to have different amounts of the desired chemicals,

Jayster

Groove · May 24, 2015, 3:45pm

Is there any web site i can order yokukasan supplement? I live in the USA.

Jayster · May 24, 2015, 3:50pm

Fromn Wikipedia:

Clinical evidence

In 2005, Iwasaki et al. (Japan) reported that YKS improved behavioral and psychological symptoms in dementia (BPSD), such as hallucination, delusion, agitation, and aggression.[5] Since then, many studies showing the effects and mechanisms of YKS on psychosomatic and neurological symptoms have been published as below. Iwasaki et al. reported a 15 dementia with Lewy bodies (DLB) patient case series where hallucinations and other BPSDs were successfully improved with YKS treatment.[6] Mizukami et al. (2009) reported their expanded crossover trial of the effects of YKS on BPSD.[7] Finally, a meta-analysis showed the YKS effects on BPSD.[8]

Shinno et al.reported that YKS was effective for control of psychiatric symptoms and improvement of sleep structure in patients with BPSD.[9] Miyaoka et al. reported that YKS successfully treated neuroleptic-induced tardive dyskinesia[10] and borderline personality disorder.[11] Satoh et al. have also recently reported that YKS improved involuntary movements in Huntington’s disease.[12] These clinical reports suggest that YKS has an antipsychotic like effect without causing extrapyramidal symptoms.

andrea866 · May 31, 2015, 4:37pm

soon I will start to give youkakansan my sister who suffers from schizophrenia …
I will let you know the results …
some of you have already tried yokukansan?

andrea866 · June 6, 2015, 2:32pm

http://www.readcube.com/articles/10.1111%2F1346-8138.12578?r3_referer=wol&tracking_action=preview_click&show_checkout=1&purchase_referrer=onlinelibrary.wiley.com&purchase_site_license=LICENSE_DENIED_NO_CUSTOMER

ncbi.nlm.nih.gov

Yokukansan (TJ-54) for treatment of very-late-onset schizophrenia-like psychosis: an open-label study.

T Miyaoka, R Wake, M Furuya, K Liaury, M Ieda, K Kawakami, K Tsuchie, M Fukushima, K Ishihara, T Araki, S Hashioka and J Horiguchi, Phytomedicine : international journal of phytotherapy and phytopharmacology, May 2013 15

Although schizophrenia affects all age groups, late or very-late-onset schizophrenia-like psychosis has not been well studied, and various treatment issues remain unresolved. The objective of the present study was to evaluate the efficacy and safety of yokukansan (TJ-54), Japanese herbal medicine, monotherapy in a diagnostically homogenous group of elderly patients without cognitive impairment suffering from very-late-onset schizophrenia.Forty patients of mean age 73.1±4.8 years, fulfilling both the recent consensus criteria for very late-onset schizophrenia-like psychosis and the DSM-IV-TR criteria for schizophrenia, were assessed by the brief psychiatric rating scale, the clinical global impression scale-severity, and positive and negative syndrome scale at baseline and after 4 weeks administration of TJ-54 (2.5-7.5 g/day). In addition, abnormal movements were evaluated with the Simpson-Angus scale, Barnes Akathisia scale, and abnormal involuntary movement scale.A highly significant (p<0.001) improvement on all measures of psychotic symptomatology was observed in all patients. TJ-54 was very well tolerated by the patients, and no clinically significant adverse effects were observed. Scores on all abnormal movement scales did not differ significantly prior to and after TJ-54 treatment.Preliminary results indicate that TJ-54 appears to be an efficacious and safe herbal medicine for treatment of very-late-onset schizophrenia-like psychosis.

http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0116275&representation=PDF

ncbi.nlm.nih.gov

Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+/MPTP-induced cytotoxicity in vitro and in vivo.

AR Doo, SN Kim, JY Park, KH Cho, J Hong, K Eun-Kyung, SK Moon, WS Jung, H Lee, JH Jung and HJ Park, Journal of ethnopharmacology, Sep 2010 15

A traditional herb, Yi-Gan San, has been widely used for the management of neurodegenerative disorders in traditional East Asian Medicine.The present study investigated the neuroprotective effects of Yi-Gan San in 1-methyl-4-phenylpyridine/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cytotoxicity in vitro and in vivo and sought to clarify its underlying mechanisms.The effect of Yi-Gan San on 1-methyl-4-phenylpyridine was measured in terms of 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assays, caspase-3 activity, and western blot analysis of phosphorylated Akt, one of the survival-related signaling proteins in SH-SY5Y cells. The effects of Yi-Gan San were also confirmed in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonian mouse model using a rotarod test and tyrosine hydroxylase-immunohistochemistry.Pretreatment of Yi-Gan San with 1-methyl-4-phenylpyridine showed a significant protective effect on SH-SY5Y cells and significantly decreased the level of caspase-3 activity compared to the values for the 1-methyl-4-phenylpyridine-treated cells. This process increased the protein expressions of phosphorylated Akt, and an inhibitor of phosphatidylinositol 3-kinase (PI3K)/Akt, LY294002, significantly decreased this protective effect of Yi-Gan San. In the mouse Parkinson's disease model, treatment with Yi-Gan San also significantly improved motor functioning and prevented dopaminergic loss related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine challenge.Using both in vitro and in vivo methods, this study revealed that Yi-Gan San has neuroprotective effects and rescues dopaminergic neurons from 1-methyl-4-phenylpyridine/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity, possibly via the PI3K/Akt pathway.

ncbi.nlm.nih.gov

[Clinical usage of Yi-gan san-schizophrenia, borderline personality disorder, dyskinesia etc-].

J Horiguchi, Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2012

Yi-gan san (YGS, yokukan-san in Japanese) was developed in 1555 by Xue Kai as a remedy for restlessness and agitation in children. Prompted by the increasing life expectancy of the Japanese population, geriatricians have begun to use this traditional regimen for behavioral and psychological symptoms of dementia in the elderly. Moreover, we reported that YGS therapy is a well-tolerated and effective remedy that improves the symptoms of schizophrenia., borderline personality disorder, Charles Bonnet Syndrome, pervasive developmental disorder. Asperger's disorder, neuroleptics induced tardive dyskinesia, and restless legs syndrome. In a pilot investigation, we administered YGS as an open-label adjunct to antipsychotic medication to patients with treatment-resistant shizophrenia, borderline personality disorder, Charles Bonnet Syndrome, pervasive developmental disorder, Asperger's disorder, neuroleptics induced tardive dyskinesia. The present lecture summarizes the available data based on the above our data. In addition, we extend our discussion to the potential applications of YGS for combining this treatment with cellular and molecular therapy.

BarkingDog · June 6, 2015, 3:18pm

just like ■■■■■■■ vegetables, fruits, nuts and stuff.

SzAdmin · February 9, 2016, 11:54pm

Did you try this with your sister? Did it have any positive impacts? Is she still taking it? How long did she / has she taken it?

andrea866 · March 28, 2016, 9:40am

i did not try yokukansan on my sister because her doctor did not know yokukansan and its property