Wow - this would explain why schizophrenia is so difficult to understand and treat - though I suspect that most cases are probably the result of a much smaller number of contributing factors / genetic predisposition factors.
“Through additional simulation-based analyses, the researchers estimated that there are more than 20,000 causal SNPs (single nucleodide polymorophisms or small variations in genes) for schizophrenia.”
Which then encounter gawd knows how many potential situations in the specific environments during the pre-natal, peri-natal, neo-natal, infant, toddler, pre-school, kindergarten, grade school, etc., etc. environments. We know this much, however, from the study of epigenetics (see https://en.wikipedia.org/wiki/Epigenetics): The earlier “it” happens, the more likely it is to produce “major” effects.
And this from the study of treatment efficacy: The more the pt knows and accurately understands about both the genetic and environmental circumstances of his or her particular case, the better the outcome tends to be.
I know it may seem controversial to some here, but I will suggest that less concern with what exactly caused it and more with what the circumstances actually are and what can be done about those precise circumstance will better serve patients’ recovery objectives.