“The D4-binding compounds identified from ZINC are among the most potent ever reported,” said co-senior author Bryan L. Roth, MD, PhD, the Michael Hooker Distinguished Professor of Pharmacology at the UNC School of Medicine. "This kind of rapid screening of millions of potential compounds is a major step toward creating better medications for many illnesses, and in the case of the D4 receptor, psychiatric conditions.
For example, based on the success rate in lab tests of more than 500 D4 receptor-targeting molecules flagged by virtual screening, the authors estimate that the full ZINC database contains nearly half a million never-before-synthesized compounds capable of targeting this key psychiatric protein.
“One of the bubbles constraining novel drug discovery has popped,” Shoichet said. “Chemists have struggled with our inability to access large, diverse sets of chemical structures for decades. Now, with patient support from the National Institutes of Health, an unexpected confluence of new technologies has suddenly cracked opened a door that long seemed locked.”
Thats a big deal. Hopefully soon they will have better meds for us.