Unrecognized clozapine-related constipation leading to fatality - a case report

Something that families should be aware of if someone is taking Clozapine. It seems low risk, but watch for the constipation.

note:

Several cases of fatal sepsis have been reported in neutropenic patients and emphasis is placed on monitoring for agranulocytosis; however, clozapine also causes intestinal hypomotility and constipation, which if unrecognized can lead to intestinal obstruction, bowel necrosis, and intra-abdominal sepsis.

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