The patients with first-episode schizophrenia experienced more severe childhood trauma and had lower serum brain-derived neurotrophic factor levels than healthy controls.
Childhood trauma might contribute to the clinical symptoms of schizophrenia by affecting brain-derived neurotrophic factor levels. Perhaps we can prevent schizophrenia by reducing childhood traumatic experiences.
Wasn’t there recently an article here about SSRIs prescribed to kids from 10-12 years old reducing the incidence of schizophrenia in an at risk group? The authors speculated that it could be the increase in BDNF.
The people developing MIN-101 are also speculating similarly.
Dysregulation of BDNF has been described in the pathophysiology of schizophrenia and several other neuro-psychiatric disorders. Therefore, in addition to the known neurotransmitter pathways targeted by roluperidone, particularly the serotoninergic 5-HT2A and the sigma2 pathways, the effect of roluperidone on BDNF suggests that this investigational compound may have the potential for disease modification and improved neuroplasticity.
Seems like they need to try it on at-risk people. Or, because of the (possible) mechanism, for much longer periods of time.