Synthetic Cannabinoids—Further Evidence Supporting the Relationship Between Cannabinoids and Psychosis


Consumption of synthetic mind-altering compounds, also known as “new psychoactive substances,” is increasing globally at an alarming rate. Synthetic cannabinoids (SCs) are among the most commonly used new psychoactive substances. They are usually purchased as marijuana-like drugs, marketed as herbal blends and perceived as risk-free by inexperienced users. Yet, contrary to Δ9-tetrahydrocannabinol, SCs may lead to severe health consequences, including anxiety, tachycardia, hallucinations, violent behavior, and psychosis. This review focuses on the latest (2010–2015) evidence of psychotic symptoms induced by ingestion of products containing SCs. Reports suggesting that SCs may either exacerbate previously stable psychotic symptoms (in vulnerable individuals) or trigger new-onset psychosis (in individuals with no previous history of psychosis) are reviewed. Pharmacology and toxicology of these compounds are discussed, with particular reference to their psychoactive effects.

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I almost commited suicide after experiencing one blend of synthetic marijuana.

I think this could have been the case with my son. We hadn’t seen signs of psychosis prior to his use of K2 ( and we weren’t really looking ), but he was having severe hallucinations and behaved so bizarre that it’s painful to think about. He claims to have used it only that one time, but things were never the same.

K2 messed me up really bad. that was 4 yrs ago. still screwed up