(supplement) Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia

https://www.iherb.com/pr/Doctor-s-Best-Fisetin-with-Novusetin-100-mg-30-Veggie-Caps/43592

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Due to the lack of safety data, pregnant women and children should avoid fisetin supplements.

Drug Interactions
Supplement-drug interactions can be dangerous and, in rare cases, even life-threatening. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering.

The liver uses the same pathway to process fisetin as it does for the blood-thinning agent warfarin (Coumadin). This can, in theory, increase the effects of warfarin [107, 108].

Fisetin substantially reduces blood sugar in diabetic animals. The combination with blood sugar-lowering drugs may further reduce sugar levels [30, 31, 32, 33, 34, 35

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I can’t take it as it could interact with Metformin.

Strawberries appear to be the best food source, with about 10 medium strawberries having 20 mg of fisetin (vs the 100 mg in the supplement dose size.) I did not look at how much the mice were given, but it was injected into their stomachs so probably a lot.

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There’s not enough safety data on it, so I personally won’t be taking it as a supplement.

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