Sep-363856

[Aziz]

How do you think Xanomeline would affect negative symptoms?

I am not sure how muscarinic receptors affect dopamine. KarXT acts on M1 and M4 muscarinic receptors as an agonist. I found this: “In this study, we showed that dopaminergic neurotransmission is highly dependent on M4 cholinergic muscarinic receptor function” “We propose that M4 receptor agonists could represent an innovative strategy for the treatment of pathologies associated with hyperdopaminergia.” https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.04-1575fje