Semiconscious, Distorted Rumination >>> Distress & Depression

Depressive ruminations and the idling brain
New analysis explores neural processes behind depressive rumination

Depressed people often find themselves preoccupied with guilty, shameful, or self-defeating thoughts for large parts of their day. These thoughts not only distract from other activities but also fail to resolve the underlying life issues. Further, the ideas that receive focused attention in these depressive ruminations are frequently quite distorted and lead to distress.

The way that depressed people repetitively attend to these negative thoughts in an unproductive manner reflects the reasoning behind use of the term ruminations – because they call to mind the repetitive chewing of cud by ruminants like cows or goats.

The propensity for rumination in depression has been well characterized. However, a new study by Dr. J. Paul Hamilton at the Laureate Institute for Brain Research and his colleagues at Stanford University sheds light on the brain mechanisms giving rise to these symptoms.

Their work highlights the interplay of a brain region implicated in depression, the subgenual prefrontal cortex (sgPFC) and a brain network involved in reflection, sometimes called the default mode network (DMN). The DMN becomes activated when the brain’s task-oriented circuits are not engaged, i.e., during times of self-referential thought.

By reanalyzing existing studies, Hamilton and colleagues show that depressive ruminations are more likely to emerge in depression when the firing of the sgPFC, signaling depressed mood, is more tightly coordinated with the firing of the DMN. They propose that the observed increased connectivity reflects a functional integration of sgPFC and DMN processes which, in turn, support rumination in depression.

“This study shows that depression distorts a natural process. It would seem that normally the subgenual prefrontal cortex helps to bias the reflective process supported by the default mode network so that we can consider important problems in the service of developing strategies for solving them,” commented Dr. John Krystal, Editor of Biological Psychiatry.

“However, in depression it seems that the subgenual prefrontal cortex runs amok hijacking normal self-reflection in a maladaptive way. This may be one reason that electrical stimulation of the sgPFC is helpful for some patients with severe or treatment-resistant symptoms of depression.”

Journal Reference:

J. Paul Hamilton, Madison Farmer, Phoebe Fogelman, Ian H. Gotlib. Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience. Biological Psychiatry, 2015; 78 (4): 224 DOI: 10.1016/j.biopsych.2015.02.020

I will add, however, that all five of the mindfulness-based cognitive psychotherapies listed below provide pts who use them with the skills to quickly pull themselves up out of such rumination.

10 StEP –


Thank you for this…

Negative thinking can become addicting… and comes around again and again.

It’s a hard cycle to break out of… I had no idea how much of it I was doing until it got brought to my attention…

It starts so small and grows so quickly… until of course the space in my head is consumed… then I have to empty and reset.

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If you’re into the topic now, you can find out a lot more from Martin Seligman’s work on “learned helplessness” and “learned optimism” at