Ale
February 21, 2020, 5:37pm
1
2 Likes
I believe low protein levels inhibit the healing of the blood-brain barrier.
People with traumatic brain injury are encouraged by experts to eat as much protein as a bodybuilder would, to facilitate healing, even.
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Ale
February 21, 2020, 6:04pm
3
That would explain how ketogenic diet has healed some schizophrenics
Ale
February 21, 2020, 6:15pm
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It’s not dietary protien.
One of the things genes do (not all of them) is code for proteins.
Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene.
At this point it is unclear if there’s less of this synaptic protein because the schizophrenia caused synaptic loss, or the reduction in the protein caused the loss, or some other possibility.
This is a different protien found to be reduced only in specific areas of the brain in SZ.
AS Gibbons, D Hoyer and B Dean,
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry , Feb 21 2020
SMADs are a family of signal transduction factors that mediate signalling of the TGFB-superfamily of cell regulatory proteins. A recent transcriptomic analysis of post-mortem, cortical tissue from subjects with schizophrenia found decreased mRNA expression of SMAD2 and SMAD4 in the dorsolateral prefrontal cortex (DLPFC) associated with the disorder. To expand this initial finding, we sought to determine whether SMAD2 and SMAD4 protein were also altered in the cortex from subjects with schizophrenia.Western blotting was used to measure SMAD2 and SMAD4 protein levels in DLPFC and anterior cingulate cortex (ACC) taken post-mortem from subjects with schizophrenia (n = 20) and matched control (n = 20) subjects.Compared to controls, levels of SMAD4 were 25% lower in the DLPFC and 38% lower in the ACC from subjects with schizophrenia. By contrast, SMAD2 levels were not altered in either DLPFC or ACC.Our finding of lower SMAD4 protein in the cortex suggests there are likely to be abnormalities in cortical TGFB-superfamily signalling in schizophrenia.