Schizophrenia medical theories

There is a lot of theories but these are the main ones. Reality is likely a mix of all these theories.
Yes, I love medicine. I did study some in neuro and psy university courses. No, I am not a dr.

  • Genetic theory
  • Dopamine hyperactivity (Positive
    symptoms)
  • Serotonin imbalance (Positive
    symptoms)
  • Glutamate (NMDA and AMPA receptors)
    hypoactivity
    (Negative and Cognitive symptoms)
  • Hypofrontality (Negative symptoms)
  • Parietal lobe cortex brain tissue loss (Positive
    and Cognitive symptoms)
  • Neurodevelopment abnormalities
  • Neural connections misconnection and weak
    connections.
  • Incorrect neural connection pruning (shaping)
    or failure
  • (Newest) Acetylcholine (Muscarinic
    and Nicotinic receptors) hypoactivity (New AP
    Xanomeline Phase 3 trials)

Do you think they will find a full cure for SZ one day?
I can’t wait to try Xanomeline in a couple of years.

There’s also one about histamine receptors, which is something my new antipsychotic, Vraylar, targets. It makes sense because I have very high levels of histamine, and when I got off my antihistamine, I had my break.

I’m also very interested into the science of both schizophrenia and how medication works. So, while I’m off of school for a few weeks, I’ll research more into the science.

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Did your negative and cognitive symptoms improve on it?

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It hasn’t begun to work yet, so I’m still going off of risperdal. But I’d imagine that my negative and cognitive symptoms will improve as they’re something that I’ve been struggling with recently, especially lack of motivation. I’m going to be completely on Vraylar in about a month when I can lower my risperdal dose.

Wikipedia says its good for cognitive symptoms. Nothing about negative symptoms. Where did you read that it acts on histamine? They only say its different than other AP because it reduces dopamine when dopamine is high and increases dopamine when dopamine is low. Its a modulator, not an antagonist. Other APs except Abilify completely block dopamine all the time.

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I read a NCBI article on it, abilify, and some other medication.

I will ask my psy about it but I don’t think its covered by insurance in Canada. Thanks!

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