During the study, Peng Zheng and colleagues examined the fecal matter from a sample of schizophrenics and compared them with those from healthy controls. They found that schizophrenics had strikingly low diversity of bacterial species from the Lachnospiraceae and Ruminococcaceae families, species that are normally found in abundance. In contrast, species from the Veillonellaceae family were increased in schizophrenic patients. This difference is so stark, in fact, that the fecal matter samples alone could be used to predict whether a person was schizophrenic or not.
To extend this finding, Zheng and colleagues took these fecal matter samples and transplanted them in mice — some mice received fecal matter from schizophrenics, and some from the healthy subjects. By receiving fecal matter transplants, the mice also received a dose of the donor’s microbiome.
It’s difficult to accurately assess whether a mouse is behaving in a way that corresponds with schizophrenia, but, over the years, researchers have characterized several behaviors that correspond to schizophrenia in mice. The researchers found that mice who received a fecal transplant from schizophrenics were more hyperactive and more easily startled, both of which are consistent in mice models of schizophrenia.
Altogether, these findings suggest that there is, indeed, a strong link between the gut microbiome and the schizophrenic brain, perhaps even a causal one, although more research is needed to definitively say. However, the researchers do note that events that change the microbiome are associated with schizophrenia, implying a connection does indeed exist:
In the context of these findings, several events shown to influence composition of the gut microbiome, especially during the microbiome’s establishment/dynamic period in infancy — e.g., cesarean versus vaginal birth, breast versus formula feeding, or early life antibiotic treatment — have all been associated, to some degree, with risk or onset of [schizophrenia
Eating raspberries may be a great way to adjust the missing bacteria and eliminate the overactive bacteria
Obese diabetic db/db mice were used in this study and assigned to two experimental groups (with and without raspberry supplementation). Fecal samples were collected at the end of the supplementation period (8 weeks) and used for bacterial 16S rRNA gene profiling using a MiSeq instrument (Illumina). QIIME 1.8 was used to analyze the 16S data. Raspberry supplementation was associated with an increased abundance of Lachnospiraceae ( p = 0.009), a very important group for gut health, and decreased abundances of Lactobacillus, Odoribacter , and the fiber degrader S24-7 family as well as unknown groups of Bacteroidales and Enterobacteriaceae ( p < 0.05). These changes were enough to clearly differentiate bacterial communities accordingly to treatment, based on the analysis of UniFrac distance metrics.
Out of a total of 25 differentially abundant species (bacteria and fungi), 6 microbial species were more abundant in cases than controls after adjusting for relevant covariates. Lactic acid bacteria were relatively more abundant in schizophrenia including Lactobacillus and Bifidobacterium with the largest effect found in Lactobacillus gasseri which appeared to be at least 400 times more abundant in schizophrenia patients than in controls. The study also found that 18 metabolic pathways that were enriched and 14 decreased in schizophrenia relative to controls. Pathways that were significantly altered in schizophrenia were related to environmental information processes such as saccharide, polio, and lipid transport systems
All in all trying eating at least 3oz of rasberries a day it may be a great way to adjust your gut and heal the the microbiome issues at the root of schizophrenia which contribute to the glutamate gaba brain axis dysfunction.