Sarcosine Reduces Symptoms in Schizophrenia

HuckFinn · December 10, 2015, 9:24pm

I’m taking a gram a day. Half two times. I feel pretty good… better than before… I have a bit of sz symptoms tho. Not much but a little more present in volume not frequency tho

anon31257746 · December 13, 2015, 6:23pm

I started sarcosine again. Day 4. I’ll try to take it for atleast a month

cactustomato · December 16, 2015, 2:09am

I just bought my sarcosine.

anon89143308 · December 16, 2015, 6:46pm

i just got 180 grams
how soon for effects

SzAdmin · December 16, 2015, 7:56pm

fuzzywamba · December 18, 2015, 8:44am

Im going to give these Brainvitaminz sarcosine a try

im currently on 3mg Risperdal

will post feedback as soon as I have some

anon79999497 · December 23, 2015, 12:23pm

Conclusions This finding suggests N-methyl-d-aspartate receptor-enhancement therapy can improve the cognitive function of patients with schizophrenia, further indicating this pro-cognitive effect can be primary without improvement in clinical symptoms

ncbi.nlm.nih.gov

Adjunctive sarcosine plus benzoate improved cognitive function in chronic schizophrenia patients with constant clinical symptoms: A randomised, double-blind, placebo-controlled trial.

CY Lin, SY Liang, YC Chang, SY Ting, CL Kao, YH Wu, GE Tsai and HY Lane, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, Aug 2017

Objectives Hypofunction of NMDA receptor is implicated in the pathophysiology, particularly cognitive impairment, of schizophrenia. Sarcosine, a glycine transporter I (GlyT-1) inhibitor, and sodium benzoate, a d-amino acid oxidase (DAAO) inhibitor, can both enhance NMDA receptor-mediated neurotransmission. We proposed simultaneously inhibiting DAAO and GlyT-1 may be more effective than inhibition of either in improving the cognitive and global functioning of schizophrenia patients. Methods This study compared add-on sarcosine (2 g/day) plus benzoate (1 g/day) vs. sarcosine (2 g/day) for the clinical symptoms, as well as the cognitive and global functioning, of chronic schizophrenia patients in a 12-week, double-blind, randomised, placebo-controlled trial. Participants were measured with the Positive and Negative Syndrome Scale and the Global Assessment of Functioning Scale every 3 weeks. Seven cognitive domains, recommended by the Measurement and Treatment Research to Improve Cognition in Schizophrenia Committee, were measured at weeks 0 and 12. Results Adjunctive sarcosine plus benzoate, but not sarcosine alone, improved the cognitive and global functioning of patients with schizophrenia, even when their clinical symptoms had not improved. Conclusions This finding suggests N-methyl-d-aspartate receptor-enhancement therapy can improve the cognitive function of patients with schizophrenia, further indicating this pro-cognitive effect can be primary without improvement in clinical symptoms.

anon93437440 · December 24, 2015, 1:54am

Sarcosine really works wonders… along with Ltheanine.

I no longer get scifi delusions

I’m on 20 mg Olanzapine + 4 mg Risperidone every night

and

10 mg Selegiline every morning

and

large doses of L-theanine all day

and 5 grams of sarcosine.

I cured my Anxiety with Noopept.

Common POST for L-Theanine and Sarcosine

I’m not experiencing any +ve and -ve symptoms… zero [ +ve and -ve ] symptoms.

anon89143308 · December 26, 2015, 7:44pm

so it did nothing for me.

anon31257746 · December 29, 2015, 3:10am

The sarcosine is working for my motivation and avolition. It’s just not always consistent. But it really does work and that surprises me.

I stopped taking it for over a week and a half after a couple weeks use. I started getting very unmotivated again.

So started again today. Forgot I took it. An hour later I’m suddenly feeling motivated to do goal oriented activities again.

Kind of a eureka moment for me.

I will continue to give the sarcosine a go.

McSmiley · December 30, 2015, 8:36pm

Gave this to my son for about a week or two. His psychotic symptoms came back. Have stopped giving it to him. Anyone else have this happen? If so, how long does it last?

SzAdmin · December 30, 2015, 10:15pm

What dose were you giving him? Did he start slow? Was there anything else going on at the time (in terms of stress, etc.) that might account for his psychotic symptoms coming back?

PhDinschizology · December 31, 2015, 2:06am

One question here for me personally, are any of the key ingredients derived from any plants and if so, what plants?

SzAdmin · December 31, 2015, 2:25am

No - I believe that all sarcosine that is sold is manufactured in lab environments. You can read more about it here:

PhDinschizology · December 31, 2015, 4:18pm

Cool thanks for the info.

wildflower · January 1, 2016, 8:01pm

Does it help with the positive symptoms too or is it just a supplement for the negatives.

SzAdmin · January 1, 2016, 8:04pm

No - I’ve only seen research that indicates its helpful with the negative symptoms:

Hatty · January 6, 2016, 12:52am

Interesting, it suggests you need benzoate too.

SzAdmin · January 6, 2016, 1:25am

Benzoate looks interesting - anyone using it?

Sodium Benzoate For Schizophrenia sounds promising DX'd - Other

Sodium Benzoate For Schizophrenia Idea: Sodium benzoate (mostly used as food and drink preservative) is pretty damn good for Schizophrenia: Proof: They tried it: http://www.schizophreniaforum.org/new/detail.asp?id=1954 It reduced symptoms by 21%. it’s plenty. Why it could helps as I understand it with my limited knowledge: The paper is all about NMDA hypofunction hypothesis and DAAO. NMDA hypofunction is a rather accepted hypothesis about the cause of schizophrenia. And a D-amino acid oxidase (DAAO) inhibitor, such as Sodium Benzoate, will increase the level of D-Serine, which in turn reduces NMDA hypofunction. In fact, they have found out that people with Schizophrenia have too muc…

shutterbug · January 6, 2016, 2:08am

I have some. Never occurred to me to try it. Will get it cleared with my doctor and give it a try if he okays it.

Pixel.