Wave
June 10, 2015, 10:33pm
1
Did not know this, but it seems that some of the Atypicals including Risperdal can either trigger new OCD symptoms or worsen existing OCD in certain vulnerable patients.
My OCD has been off the charts lately!
I knew that Risperdal worsened my Anxiety, but now its possible that it is worsening my OCD! - I will mention this to my pdoc.
Here’s a pubmed article about it. Only 6 cases in the article though.
“In all but one case, obsessive-compulsive symptoms emerged shortly after initiation of risperidone treatment with a dose above 3 mg/day.”
B Alevizos, L Lykouras, IM Zervas and GN Christodoulou,
Journal of clinical psychopharmacology , Oct 2002
Risperidone is a novel and atypical agent with a dual antagonistic effect on 5-HT and D receptors. Open-label reports and one controlled study suggest that risperidone addition is effective in patients with obsessive-compulsive disorder refractory to treatment with serotonin reuptake inhibitors. However, risperidone has also been implicated in the production or exacerbation of obsessive-compulsive symptoms. We report six cases (schizophrenia, five cases; psychotic depression, one case) in which risperidone was effective in the treatment of the psychotic symptoms but produced obsessive-compulsive symptoms (four cases) or caused exacerbation of previous obsessive-compulsive symptoms (two cases). In all but one case, obsessive-compulsive symptoms emerged shortly after initiation of risperidone treatment with a dose above 3 mg/day. The mechanisms and risk factors for risperidone and other atypical antipsychotics to induce or exacerbate obsessive-compulsive symptoms are as yet not clear. Risperidone-induced obsessive-compulsive symptoms appear to be dose-dependent and are probably produced by serotoninergic-dopaminergic imbalance. Close monitoring of the patients receiving risperidone, especially those vulnerable to the development of obsessive-compulsive symptoms, may be of value. Gradual escalation and low final dose may be helpful.(2) (2)
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Wave
June 10, 2015, 11:03pm
3
Thanks @everhopeful !
Nice article - good info!
Yeah clozapine can do it too.
I dunno about Geodon. I become more OCD the more I feel I have to lose. I guess it’s buckling under weight.
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