Researchers use inhibitor of WNT pathway to rescue development in DISC1 disrupted brain organoids

“DISC1-mutant mini-brains showed significant structural disruptions compared to organoids in which DISC1 was intact. Specifically, the fluid-filled spaces, known as ventricles, in the DISC1-mutant mini-brains were more numerous and smaller than in controls, meaning that while the expected cells are present in the DISC1-mutant, they are not in their expected locations. The DISC1-mutant mini-brains also show increased signaling in the WNT pathway, a pathway known to be important for patterning organs and one that is disrupted in bipolar disorder. By adding an inhibitor of the WNT pathway to the growing DISC1-mutant mini-brains, the researchers were able to “rescue” them – instead of having structural differences, they looked similar to the mini-brains developed from normal stem cells. This suggests that the WNT pathway may be responsible for the observed structural disruption in the DISC1-mutants, and could be a potential target pathway for future therapies.”


We are going to learn a lot from stem cells and mini-brains. Exciting times to be alive.


Thank you for posting @twinklestars


According to the internet, drug discovery for drugs that act on the WNT pathway is a hot area, because it may be useful for many things, such as cancer and arthritis.