Researchers find key to keep working memory working

The new study shows that these prefrontal cortical circuits depend upon the neurotransmitter acetylcholine stimulating muscarinic M1 receptors aligned on the surface of neurons of the prefrontal cortex. Blocking muscarinic M1 receptors reduced the firing of neurons involved in working memory, while activating the M1 receptors helped restore neuronal firing. Because acetylcholine actions at M1 receptors are reduced in schizophrenia and Alzheimer’s disease, the M1 receptor may serve as a potential therapeutic target, the authors suggest.

Wang notes that a drug currently under development for the treatment of schizophrenia stimulates this M1 receptor and has shown promise in early clinical trials.


I believe KarXT which is currently in development does the job of stimulating M1 Muscarinic receptor


Yea KarXT is Xanomeline. It stimulates M1/M4 muscarinic receptors and reduced positive, negative and cognitive symptoms.
It will be in Phase 3 trials end of this year.


Would these technique’s help when people are ■■■■■■■ with you.