Without neurotensin signaling in the BLA, mice could no longer assign positive valence and didn’t learn to associate the first tone with a positive stimulus. Interestingly, the absence of neurotensin did not block negative valence. The animals instead became even better at negative valence, having a stronger association between the second tone and a negative stimulus.
Interestingly, stimulation of the angiotensin system may have antipsychotic effects (2020 review):
In the treatment of schizophrenia, agonism of the NTS system may serve as an antipsychotic on its own (Vadnie et al., 2016), or may serve to ameliorate the effects of a chronic antipsychotic regimen (Servonnet et al., 2017).
There’s even a tiny Russian study of Dilept, a peptide analogue of angiotensin, in 25 persons with schizotypal disorder.
Dilept demonstrated the unique spectrum of psychotropic activity: antipsychotic with stimulating action, favorable effect on negative symptoms and cognitive dysfunction. Treatment action was the most evident when dilept was used in the dose 200 mg/day. There was no evidence of any side-effects known to be typical for antipsychotics.
Although I would not hurry to believe a tiny Russian study.