Optimal Antipsychotic Dose and Dosing Interval for the Treatment of Schizophrenia


The Clinical Antipsychotic Trial of Intervention Effectiveness (CATIE) data, revealing that there were no significant differences in clinical outcomes between once- vs. twice-daily perphenazine dosing regimens; however, the mean dose of perphenazine was significantly lower with once-daily dosing than that with twice-daily dosing.

These findings suggest the possibility of effective antipsychotic treatment with lower doses and longer dosing intervals.



I came across this before. I tried taking abilify every second day and it just didn’t work out. In any case abilify wasn’t included in the study.