Schizophrenia.com

Nose to brain delivery of tailored clozapine nanosuspension

Clozapine nasal spray tested in rats.

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“Ultimately, in the case of an intranasal route, a 3.56-fold increase in brain drug concentration was observed with a 528-fold lower drug dose compared with oral administration. The results suggest that clozapine nanosuspension may be used for successful nose-to-brain delivery.”

:slight_smile:

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