Niacin didn't cure my Schizophrenia, may be something more is needed - I found why niacin doesn't work --- Magnesium was missing


#16

I will try that one of these days. So, far I’ve tried vitamin C and it helped me with this very uncomfortable emotion that SZ bringsl.


#17

I just met with a nutritionist and she shed some light on why the niacin doesn’t work. According to a micronutrient profile I had done I have 2 genetic mutations that make me 70% unable to convert folic acid into folate. I’m also deficient in vitamin B12. B12 and folate are necessary for the methylation cycle to work and being deficient in them throws the whole methylation cycle out of whack and niacin isn’t able to be metabolized. She has me on Folate and B12 for 2 months and once that gets methylation going she’ll give me niacin and it should work then. I’ll try to post a picture of the methylation cycle so you can see how this works:

The methylation cycle is also necessary for production of neurotransmitters such as dopamine and serotonin as well as glutathione which is implicated in schizophrenia. You can have the micronutrient profile done through Spectracell (http://www.spectracell.com/). It’s a few hundered bucks but it’s worth it to see if you have these mutations and deficiencies, they just draw some blood and send it off and you get the results in 2 weeks. Since I started taking the B12 and Folate I’ve started feeling pleasure in day-to-day things which has never happened before in my life! I don’t know what to do with myself. If you start taking the B12 and Folate it should have an effect immediately.


#18

Deficency b12 can cause psychosis, i hope thats the only reason to your psychosis and you can be treated with supplements without needinga medication.


#19

There is no cure for schizophrenia - antipsychotics can control schizophrenia, but they do not cure schizophrenia.
Niacin will not cure schizophrenia for certain. If I were you I would be having serious discussions with your psychiatrist, and he or she can give you appropriate medications to help you with your symptoms.
Supplements can make you physically healthier, but are far from curing schizophrenia


#20

That’s all speculation really. Niacin works on my positive symptoms 100%. All the other vitamin stuff I tried did nothing or gave me a headache


#21

I’ve been taking Bacopa extract for a week or so, and I think I have a positive reaction to it. I’ve heard a lot of people benefit from it, but can have negative effects when taken w/prescription meds so ask your Doc.

Theres a book on SZ “Recovered, not Cured” that might be able to give you some insight on the process.


#22

Folic acid supplementation had no statistically significant effect on the incidence of cancer over the course of 5 years, a meta-analysis found, but questions remain.

Among almost 50,000 individuals enrolled in 13 clinical trials, 7.7% of those receiving folic acid developed malignancies, as did 7.3% of those receiving placebo, according to Robert Clarke, MD, of the University of Oxford in the U.K., and colleagues.

This represented a nonsignificant 6% increase in various types of cancer in participants taking folic acid supplements (RR 1.06, 95% CI 0.99 to 1.13, P=0.10), the researchers reported online in the Lancet.

However, an accompanying comment urged caution in drawing conclusions from the meta-analysis.

“Although the results presented in the meta-analysis are an important addition to the debate, the complexity of the biological relation between folate and cancer requires cautious interpretation,” argued Joshua W. Miller, PhD, of Rutgers University in New Brunswick, N.J., and Cornelia M. Ulrich, PhD, of the German Cancer Research Center in Heidelberg.

Since the late 1990s, flour has been fortified with folate in the U.S. and Canada to help prevent neural tube defects, but countries in Western Europe have declined to do so out of fears of increased risks for certain types of cancer.

Epidemiologic studies had suggested that a high intake of folate was associated with lower rates of colorectal cancer and cardiovascular disease, but in the years immediately following the mandated folic acid fortification, a transient rise was reported for colorectal cancer in North America.

Adding to the concern was the finding in the Aspirin and Folic Acid Polyp Prevention Study (AFPPS) of an increase in prostate cancer and in advanced colorectal adenomas.

To explore the impact of folate supplementation on incident cancer, Clarke and colleagues conducted a literature search and meta-analysis in which they examined patient-level data for 49,621 adults who had previously had colorectal adenomas or were at risk for cardiovascular disease.

Mean age was 64, and two-thirds were men.

The doses of folic acid used in the studies varied from 0.5 mg to 5 mg per day, with the exception of one study that used a daily dose of 40 mg.

Study duration ranged from 1.8 years to 7.4 years, with an average of 5.2 years.

No increases were seen for individual types of common cancer:

Colorectal, RR 1.07 (95% CI 0.83 to 1.37)
Lung, RR 1.08 (95% CI 0.86 to 1.35)
Breast, RR 0.89 (95% CI 0.66 to 1.20)
Prostate, RR 1.15 (95% CI 0.94 to 1.41)

“Importantly,” the researchers stated, they saw no increased risk for cancer with longer treatment, although they noted that only four of the studies were of 5 years’ duration or more.

They also found no differences in cancer incidence according to age, sex, pretreatment levels of folate, or dose of folic acid.

Even in the trial with the 40-mg dose, there was no increase in incidence of cancer (RR 0.94, 95% CI 0.61 to 1.47).

The authors noted that a previous meta-analysis which relied on summary data from a smaller group of trials had identified a “marginally significant excess” in cases of prostate cancer.

However, the current analysis used individual-patient data from all of the trials, and the association of folic acid with prostate cancer supplementation seen in the AFPPS study “was most likely produced or exaggerated by the play of chance,” they stated.

They acknowledged that their analysis did not attempt to assess the longer-term effects of folic acid, suggesting that decades-long follow-up might be “feasible” in groups with linkages between cancer and death registries.

“The present meta-analysis rules out moderate increases in overall cancer incidence from folic acid supplementation,” they concluded.

In their comment, Miller and Ulrich explained that all cells, including cancer cells, require folate for the process of mitosis, and inhibiting the metabolism of folate – as occurs with anti-cancer drugs such as methotrexate – can interfere with the progression of some malignancies.

But increasing the availability of folate can increase the proliferation of cancer cells, they explained.

“Thus, folate has a putative two-faced relationship with cancer: it can protect against initiation, but promote proliferation,” they stated.

They also sounded a note of caution with regard to the statistical findings.

“Although the overall RR for cancer did not reach the conventional (and somewhat arbitrary) definition of statistical significance (ie, P<0.05), the lower bound of the [confidence interval] was very close to 1, and the overall cancer incidence increased by 6%. For prostate cancer the risk estimate was 1.15 (99% CI 0.94 to 1.41) – again, a finding close to significance,” they wrote.

“Additional epidemiological and statistical analyses are warranted to address population-based hypotheses that are consistent with our current understanding of the biochemistry and biology of folate and cancer,” they stated.


#23

I recently came to know that folic acid can prevent cancer if 400 mcg is taken daily and I was taking 5 - 50 mg daily and I was also taking B12 and Alpha Lipoic Acid. Yes I noticed that taking Cinnamon made my craving for food go away and Folic acid and B12 gave me some ability to pay attention. After I came to know about Cancer I stopped using Folic acid. I bought these health supplements only because my sister gave me 5000 Rupees. Now, I’m 34 Male single with no source of income, a complete failure. Out of money. But, I’m sure I can make up for Folic acid and B12. I know B12 is good for memory and is safe in large dosage but, what about Folic acid and the Cancer? I think Dr. Abram Hoffer took 5 mg Folic acid all his life.

My theory:

http://19january1980.blogspot.in/

http://abram-hoffer.blogspot.in/

Dr. Abram Hoffer – What Vitamins, Minerals and Supplements Abram Hoffer Took Daily:

In a 2008 Interview, Dr. Abram Hoffer (then 90 years old), described his daily multivitamin regimen.

What Vitamins, Minerals and Supplements Abram Hoffer Took Daily:

Vitamin A -30,000 IU a day

B-100 Complex - 1 a day

Niacin - Each time 1500 mg - 3 times a day

Folic Acid - 5000 mcg a day

Vitamin C - each time 1000 mg - 2 times a day

Vitamin D3 - 6000 IU a day

Vitamin E -
Each time 400 IU - 2 times a day

Selenium - 200 mcg each - 3 times a day ( good antiviral)

Calcium/Magnesium - Each time 650 mg Calcium/350 mg Magnesium- 2 times a day

Zinc - 50 mg per day

Salmon Oil (EPA/DHA) - 2000 mg a day

NAC - Each time 1000 mg - 3 times a day

CoQ 10 - Each time 100 mg - 3 times a day
Alpha Lipoic Acid - Each time 200 mg - 3 times a day



#24

Yes something more is needed, CBT and medication issued by an MD. Your theory is different from your Doctors. Abrams Hoffer was a chronic LSD user, not gaining his ideas from a multi-vitamin.


#25

he did NOT ‘use’ lsd, he studied the use of it for treatments.


#26

Research[edit]
Working in Saskatchewan with Humphry Osmond (who coined the term “psychedelic”), Hoffer and other scientists sought to find medicinal uses for hallucinogenic drugs.[15] Part of the research involved Hoffer, Osmond and their wives consuming LSD in an effort to become better acquainted with, and better understand its effects, later joined by other experimenters and their wives.[16] Their work began attracting notoriety within professional, provincial and federal and political circles, and they were courted by the emerging movement to restrict peyote as well as Native American groups that used the substance in religious ceremonies.[17] Hoffer, Osmond and others treated alcoholics with LSD. Canadian scientists reported a fifty percent success rate in one study, although Hoffer speculated that it was more likely the psychedelic experience of LSD, rather than simulated delirium tremens, that convinced the alcoholics to stop drinking.[18]


#27

Oh interesting! thanks for that info


#28

In defence of Dr Hoffer. I went to see him for a couple of visits in the mid 80s. His claim to fame was that “a cured schizophrenic is a schizophrenic who pays taxes”.

I was diagnosed in 1971 at 28 years of age, I am about to be 72. I have found his “orthomolecular” approach allows me to be maintained on a minimal dose of medication. And insofar as taxes are concerned, since 1973 I have paid out over $890,000.00 in income tax based on earned income.

On edit: For the record I am maintained on 2.5 mg of Olanzapine and it was not at all that way before learning of Hoffer.


#29

Thank you sir for being here. I do use niacin 1.5 grams thrice a day and 5000 IU D3 harmone/vitamin and, 10 mg Olanzapine.
http://abram-hoffer.blogspot.in/
Dr. Abram Hoffer – What Vitamins, Minerals and Supplements Abram Hoffer Took Daily:
In a 2008 Interview, Dr. Abram Hoffer (then 90 years old), described his daily multivitamin regimen.
What Vitamins, Minerals and Supplements Abram Hoffer Took Daily:

Vitamin A -30,000 IU a day
B-100 Complex - 1 a day
Niacin - Each time 1500 mg - 3 times a day
Folic Acid - 5000 mcg a day

Vitamin C - each time 1000 mg - 2 times a day
Vitamin D3 - 6000 IU a day
Vitamin E - Each time 400 IU - 2 times a day
Selenium - 200 mcg each - 3 times a day ( good antiviral)

Calcium/Magnesium - Each time 650 mg Calcium/350 mg Magnesium- 2 times a day
Zinc - 50 mg per day
Salmon Oil (EPA/DHA) - 2000 mg a day
NAC - Each time 1000 mg - 3 times a day
CoQ 10 - Each time 100 mg - 3 times a day
Alpha Lipoic Acid - Each time 200 mg - 3 times a day



#30

I found why niacin doesn’t work…


#31

I took 3-5 grams of niacin with irregularity for 4-5 months and I stopped taking meds for a couple of days and couldn’t sleep for 7 days and my legs started kicking air.

My elder sister gave me 5000 rupees and my mother gave me 1000 rupees and I ordered for third time, …

here is the order

1st time I didn’t know what is good and I simply ordered grapeseed extract and alphs GPC etc;

2nd time after a year or two - when I had money - I ordered niacin

This time, 3rd time I ordered NIACIN and TRIPLE COMPLEX MAGNESIUM from swansonvitamins.com
and it’s great.

Now, I use

4.5 grams of niacin - 3 divided doses of 1.5 grams each
400 mg Magnesium twice daily
Folic acid 5 - 20 mg daily
B12 500 - 2000 mcg
D3 5000 IU

Now, I’m 34 and coming January 19th I’ll turn 35. I’m male, single and a perfect loser.

If not the 10 mg Olanzapine - Antipsychotic and above Health Supplements I would be dead by now.

These things keep me normal. I know I must use 20 mg Olanzapine to stop anger but it makes me Obese and there is always a danger of Type - II Diabetes.

The only problem is I don’t have any money.

My Father is a loser Eye Specialist. My Mother is a loser Home Maker.

I inherited all the bad things from them and the good thing is, I’m intelligent.

In Paranoid Schizophrenia, Prefrontal Cortex or Working Memory is almost or completely dysfunctional so we keep failing and Temporal Lobe is also damaged so Long-Term Memory is also defective. So some Schizophrenic’s like me have an intelligent brain which is actually a loser because it is a aim-less wandering / drifting brain with almost zero of all the important memory for a healthy life style. Yes if I had money I would buy all the good things in life…


#32

your not a loser and neither are your parents. if you change your attitude that you matter as an person that will help you.


#33

#34

Hi,

I was on Olanzapine for awhile but after being hospitalized this was changed to Risperadone and Abilify. Try these two, they work for me. I am also writing a blog about my experiences if you fancy a read about my schizophrenia:

scizm.co.uk

Thanks,

Jack


closed #37