Really interesting. It sounds like this could also be one of the mechanisms by which antioxidants may be beneficial in schizophrenia. (There’s a trial right now for high risk people on whether NAC reduces conversion to psychosis). Several formulations of NAC also include B6 and B12.
The kind of B6 they use is pyridoxamine dihydrochloride, which is not available in the US, but is in Europe. That is known to inhibit advanced glycation end products (AGEs). Other B6 will resolve deficiencies, but I don’t know how effective it is otherwise.
It also leads to the formation of advanced glycation end products (AGEs) due to MG reacting with proteins, DNA, and other biomolecules, which can induce aberrant inflammation via binding to receptors for AGEs (RAGE).
This is the first report to show that MG detoxification deficits are involved in the development of schizophrenia. Considering the molecular mechanism revealed in this study, antioxidants to prevent oxidative stress and VB6 supplementation may be effective as a new therapeutic strategy for patients with MG detoxification deficits, GLO1 dysfunction and VB6 deficiency.