Name Confidence Status
Aripiprazole (Abilify)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Asenapine (Saphris)
[Preliminary Research. More than 750 people with the condition were studied, but the findings still need to be confirmed by the scientific community in an independent study of similar size.]
Sensitivity: LOW
Metabolism: HIGH
Chlorpromazine (Thorazine)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Clozapine (Clozaril)
Preliminary Research: Fewer than 750 people studied
Sensitivity: LOW
Metabolism: HIGH
Clozapine-induced weight gain
[Preliminary Research. More than 750 people with the condition were studied, but the findings still need to be confirmed by the scientific community in an independent study of similar size.]
LOW
Haloperidol (Haldol)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Iloperidone (Fanapt)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Lurasidone (Latuda)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
Olanzapine (Zyprexa)
Preliminary Research: Fewer than 750 people studied
Sensitivity: LOW
Metabolism: HIGH
Perphenazine (Trilafon)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Promazine (Sparine)
Preliminary Research: Fewer than 750 people studied
Sensitivity: LOW
Metabolism: HIGH
Quetiapine (Seroquel)
[Preliminary Research. More than 750 people with the condition were studied, but the findings still need to be confirmed by the scientific community in an independent study of similar size.]
Sensitivity: HIGH
Metabolism: REDUCED
Risperidone (Risperdal)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Thioridazine (Mellaril)
Preliminary Research: Fewer than 750 people studied
Sensitivity: HIGH
Metabolism: REDUCED
Ziprasidone (Geodon)
Preliminary Research: Fewer than 750 people studied
Sensitivity: AVERAGE
Metabolism: INTERMEDIATE
What this means:
Sensitivity high Metabolism reduced: Your genotype predicts a reduced CYP2D6 metabolic enzyme activity. Therefore, you can not properly inactivate this drug resulting to an increased potential for drug accumulation and adverse drug reactions. You should consider using this drug at lower (20-30%) than the recommended dose and monitor for side effects. OR consider alternative drug
Sensitivity low Metabolism high
CONCLUSION : Your genotype predicts a higher CYP1A2 metabolic enzyme activity. Therefore, you can efficiently inactivate this drug resulting to a lower potential for drug accumulation and adverse drug reactions but this may lead to lack of efficacy. Increase label recommended age- or weight-specific dosing by 50-100%. If metoprolol is prescribed, titrate dose to a maximum of 250% of the normal dose in response to efficacy and adverse events. If no response, consider alternative drug which is not metabolized by CYP1A2.
https://geneticoncept.com/ You have to pay and then upload your 23andMe raw data.