i found this pretty interesting as i take the lithium orotate as supplement
this part especially:
A partial block of AIH (amphetamine-induced hyperlocomotion) was maintained by LiCO at doses of 15 mg/kg or greater in males and 20 mg/kg or greater in females. In contrast, a near-complete blockade was observed for LiOr concentrations equal to or exceeding 1.5 mg/kg in both males and females, indicating improved efficacy and potency.