I feel the best I ever have on Rexulti.
I don’t know how potent it is, but I’m on half the max dose and my positive symptoms are under control.
Plus it has gotten rid of most of the depression I have.
I believe that my depression was so severe it contributed to my psychosis.
The most potent AP I ever took was Clozapine.
I felt great on it but the side effects were bad and I didn’t really care for the blood tests.
As far as Haldol, I took 15 mg and couldn’t tell I was on anything at all. It was as if I were on a placebo.
Seroquel knocked me out cold but when I was awake I had all the issues I had without it. I’ve tried a lot of them. None have helped me.
Invega gave me severe akathisia and bodily harm urges, Latuda resulted in me making a plan, Seroquel calmed me down but made me eat, gain weight, and gave me strong half-asleep hallucinations. Zyprexa gives me mild akathisia, makes voices less frequent, and makes disassociation happen a lot less, and causes none of the negative effects from the other drugs. So far for me Zyprexa is the winning drug, but I haven’t tried clozapine yet and the doctor wants to. We’ll see about that in the future.
Everybody seems to react differently though. My first instinct was to warn everybody away from the drugs that had bad side effects for me, but I came to realize that some people don’t have bad effects and the drug actually works for them, so I try to keep that in mind now.
Latuda started out as most effective but eventually didn’t work at all. The first two drugs I used (haldol, and one whose name I’ve forgotten) were good for sleep after having barely slept for months but didn’t do much for the voices (I’ll admit I didn’t give those drugs the maximum chance due to side effects). I also had side effects for abilify and geodon so I don’t know. Seroquel was weak although I was never given the therapeutic dose for it. I tried olazapine but my Mother wanted me to get off of it because I ended up spitting when I talked so I put my hand over my mouth as a result (and possibly other reasons). It actually seemed to be otherwise OK. The main drugs that have worked have been Risperdal, Invega, and loxapine as an addition although the voices never completely went away and I gained a ton of weight.
Clozapine –0·88 (–1·03 to –0·73)
Amisulpride –0·66 (–0·78 to –0·53)
Olanzapine –0·59 (–0·65 to –0·53)
Risperidone –0·56 (–0·63 to –0·50)
Paliperidone –0·50 (–0·60 to –0·39)
Zotepine –0·49 (–0·66 to –0·31)
Haloperidol –0·45 (–0·51 to –0·39)
Quetiapine –0·44 (–0·52 to –0·35)
Aripiprazole –0·43 (–0·52 to –0·34)
Sertindole –0·39 (–0·52 to –0·26)
Ziprasidone –0·39 (–0·49 to –0·30)
Chlorpromazine –0·38 (–0·54 to –0·23)
Asenapine –0·38 (–0·51 to –0·25)
Lurasidone –0·33 (–0·45 to –0·21)
Iloperidone –0·33 (–0·43 to –0·22)
The difference in medications is how they affect the psychosis. One medication is not necessarily stronger than another. They are similar in efficacy. You don’t really need strong, just have to be the right medicine.
On top of that, it depends on the dose and mode of administration. IV-administered antipsychotics are most potent, and oral forms are the least.