L-lysine as an adjunct to risperidone in patients with chronic schizophrenia

anon79999497 · September 18, 2014, 3:14pm

ncbi.nlm.nih.gov

L-lysine as an adjunct to risperidone in patients with chronic schizophrenia: a double-blind, placebo-controlled, randomized trial.

A Zeinoddini, M Ahadi, M Farokhnia, F Rezaei, M Tabrizi and S Akhondzadeh, Journal of psychiatric research, Dec 2014

Increasing evidence suggest that the nitric oxide signaling system of the brain may contribute to the pathophysiology of schizophrenia, making this system a target for development of novel therapeutics. The objective of this study was to investigate the efficacy and safety of L-lysine as an adjunctive to risperidone in the treatment of patients with chronic schizophrenia during an 8-week trial. Seventy-two chronic schizophrenia inpatients with a Positive and Negative Syndrome Scale (PANSS) total score of ≥ 60 participated in a randomized, double-blind, placebo-controlled trial in the active phase of their disease and underwent 8 weeks of treatment with either L-lysine (6 g/day) or placebo as an adjunctive to risperidone. Patients were evaluated using PANSS and its subscales at baseline and weeks 2, 4, 6 and 8. The primary outcome measure was to evaluate the efficacy of L-lysine in improving schizophrenia symptoms. Repeated measures analysis demonstrated significant effect for time × treatment interaction on the PANSS total (P < 0.001), negative (P < 0.001) and general psychopathology (P < 0.001) subscale scores but not the PANSS positive subscale scores (P = 0.61). The frequency of adverse events (AEs) did not differ significantly between the two treatment groups and no serious AE was observed. The present study demonstrated that l-lysine can be a tolerable and efficacious adjunctive therapy for improving negative and general psychopathology symptoms in chronic schizophrenia. However, the safety and efficacy of higher doses of l-lysine and longer treatment periods still remain unknown.Iranian registry of clinical trials (www.irct.ir): IRCT201202201556N33.

Skims · September 20, 2014, 2:36pm

I had to look up what L-lysine was.

It’s an amino acid -“L-Lysine is a necessary building block for all protein in the body. L-Lysine plays a major role in calcium absorption; building muscle protein; recovering from surgery or sports injuries; and the body’s production of hormones, enzymes, and antibodies.”
It can be taken by mouth or as a cream (for herpes).
It also acts on Serotonin in the gut and brain.
And its found naturally in: eggs, meat (specifically red meat, lamb, pork, and poultry), soy, beans and peas, cheese (particularly Parmesan), and certain fish (such as cod and sardines).

bear371 · September 21, 2014, 9:19am

I’m getting L-Lysine in Freeform amino acids. http://www.vitaminshoppe.com/p/solgar-essential-amino-complex-30-veggie-caps/sl-1011 It works very very well, however the effects wear off quicker than those from vitamins.

Topic		Replies	Views
L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial News	14	1269	February 10, 2018
I ordered some L-Carnosine Medications	14	1132	February 18, 2018
Finally started taking L-carnosine Medications	38	2057	April 16, 2018
Anyone trying zinc sulfate? Medications	1	462	April 28, 2018
Amino Acid - L-Lysine - New Treatment for Schizophrenia - Has it Helped You? DX'd - Other	103	16933	April 29, 2018

L-lysine as an adjunct to risperidone in patients with chronic schizophrenia

Related topics