Schizophrenia.com

Key modifier found in genetic deletion related to neurodevelopmental disorders

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Among all the pairwise knockdowns that the research team tested, one particular gene stood out as having a large effect on the impact of all the other genes in the 3q29 deletion. The NCBP2 gene codes for a protein that is part of the “nuclear cap-binding complex,” which binds to the end of RNA molecules and plays a role in RNA regulation, transport, and decay in the cell. The main impact of NCBP2 interactions was the disruption of the cell cycle and increased “apoptosis”—cell death.

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