Both (though Vraylar is called Reagila here in Europe), but only up to 3 mg of the former. I’m currently taking 350 mg of clozapine, and I’m thankful to have escaped the weight gain, but sedation (so I take it close to bedtime) and disruption of the swallowing reflex (so I have to chew carefully and put a towel over my pillow) is bad enough. For me it does not do anything for negative symptoms but I’ve read that for some people it is the best; the explanation is probably that my negative symptoms are due to depression and not psychosis.
-Albert.