Is it possible to become resistant/build tolerance to antipsychotic medication?

Medications
1

This pattern has happened several times in my life, where I become stable on a med, I seem like I’m fine. And then several months later I’m having symptoms again and I have to ride the med carousel again.

I was wondering if that was because I grew resistant to the medicine, much like one can gain tolerance to benzos.

Just a thought, and I was curious if any of y’all knew the answer.

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I’m stuck in this cycle of starting a med that works great, then having symptoms after a while and needing the dose upped, until I’m on max dosis and then starting over with another med

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3

There isn’t such thing as a ap resistance.
AP are blockers, dopaminergetic/serotominergetic/noradrenaline(if I remember correctly) blockers. So you can’t build up tolerance, but sometimes the dose you’re on doesn’t do its job so good because there’s more stimuli wich affect you.

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4

I’ve wondered the same thing. I have to up doses and try new meds all the time.

5

Paging @everhopeful what’s the term for how abilify doesn’t have any tolerance?

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I’ve been on perphenazine for fifty years.

Jayster

8

wow thats along time. do you still hear voices?

9

Well, I don’t hear external voices. But my head has chatter in it most of the time.

@maniuk