Intra-Cellular Therapies to Present Data on Lumateperone


This is the first I’ve heard of it being investigated for substance abuse. I didn’t know it acted on opioid receptors.


Kava works on opiod receptors and it has a street reputation as an anti psychotic.

Did you know; when you cry, endorphins flood your opiod receptors ?

I’m guessing this med will try to treat the negative symptoms of SZ, primarily focusing on depression.


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That is their other drug, ITI-333.

As far as I know, Lumateperone does not act on opiod receptors.

ITI-333 isn’t being trialed in schizophrenia, but wasn’t there some news on opiod receptor dysfunction in schizophrenia recently?


Thanks, I misunderstood. I didn’t catch anything about opioid receptor dysfunction in schizophrenia, but it could explain why people with Sz are at an increased risk for substance abuse disorders.

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I found it:

Reduced mu opioid receptor availability in schizophrenia revealed with [11C]-carfentanil positron emission tomographic Imaging

I don’t know whether this ITI-333 would help with that reduced availability or not. Not sure if it is an agonist or antagonist.

Edit: ITI-333 is a MOR partial agonist. I really don’t know what that might mean for schizophrenia.