Improving Cognition via Exercise (ICE) in Schizophrenia
Mount Sinai IRB Protocol: 17-02426
Rationale: People with schizophrenia display a broad range of cognitive difficulties that have been identified as major determinants of poor functioning and disability. The goal of the present study is to examine the potential of physical exercise training to improve cognition, daily functioning, and biomarkers of cognitive change .
Study Design and Interventions: Following a baseline research assessment, participants will be randomized into aerobic exercise training or stretching & toning exercise training. Participants in both groups will take part in a 12-week, 3 times per week, 1-hour training program, in addition to their regular treatment. Participants may continue to be treated by their current psychiatrist/clinicians during the study.
Compensation: Participants will be paid up to $260 for completion of all the study’s research assessments, along with reimbursement for travel expenses.
Diagnostic, Clinical, Cognitive and Fitness Research Assessments will be completed at the beginning of the study and will include interviews, questionnaires, measures of cognitive and daily functioning, along with a physical fitness test (VO2max). Following the baseline research assessment, participants will be randomized to attend aerobic exercise or stretching & toning exercise training over a 12-week period, with follow-up research assessment completed after 6- and 12-weeks. Urine and Blood Samples will be collected at the beginning of the study and at the 6- week and 12-week research assessments. Physical Activity Monitoring will be completed at the beginning of the study and after 12 weeks. The monitoring will involve a 7-day ambulatory assessment period at the home environment using a small activity monitor worn on the wrist.
For additional information about the study and eligibility requirements, please contact:
Dr. David Kimhy
Dr. Luz H. Ospina