Improvement of Psychotic Symptoms and the Role of Tissue Plasminogen Activator

“tPA activity is influenced by lifestyle interventions and nutritional supplements that may ameliorate psychotic symptoms …”

“we analyze the role of tPA in the mechanism of action of hormones and medications effective in mitigating psychotic symptoms, such as pregnenolone, estrogen, oxytocin, dopamine D3 receptor antagonists, retinoic acid, valproic acid, cannabidiol, sodium nitroprusside, N-acetyl cysteine, and warfarin. We also review evidence that tPA participates in the mechanism by which electroconvulsive therapy and cigarette smoking may reduce psychotic symptoms.”

“Cognitive functions, which are related to the outcome of schizophrenia and are little influenced by antipsychotic treatment, depend on tPA-mediated synaptic remodeling.”

TL;DR tPA activity may be increased with exercise, a low carb diet, omega 3, B vitamins, D3 receptor antagonists, valproate, sodium nitroprusside, cannabidiol, NAC, and a couple other things.