#Identifying rare disease-associated genetic variants in patients with severe schizophrenia
A small sample (112 patients) was analyzed. Quote:
More than 48% of individuals with extremely treatment-resistant schizophrenia carried at least one of the rare, damaging variants, versus approximately 30% of those with typical schizophrenia and 25% of the control group. The severe schizophrenia group also had a higher variant burden in genes previously associated with schizophrenia than the group with typical schizophrenia.