How about dopamine agonism instead of antagonism for cognitive impairment in schizophrenia?

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So far the approach has been to antagonize the dopamine receptors in antipsychotics.
How about agonizing the dopamine receptors?
Perhaps this will solve severe cognitive impairment associated with schizophrenia?

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There is a theory about agonizing dopamine receptors in the prefrontal cortex (mostly D1). So far it hasn’t translated into good medicine, but there’s hope.

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it may be… but my problem is negative symptoms…i am waiting min 101 and sep 856…!!!

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Ugh that’s what naltrexone is and it has had amazing results on my sza…

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is it an anti psychotic …???

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No it’s a dopamine agonist. But it’s more essential than my antipsychotic. I went from 25 mg abilify. Then I started 50 mg naltrexone and now I’m on 10 mg abilify! I think I could go down to 5 mg. But still need SOME abilify.

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I’m not convinced it’s a dopaminergic agonist. All in all, I fail to see how it could be beneficial for Sz/SzA… but @Goyankees is the living proof that it does something good :slight_smile:

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All I know is when I started taking it I had 12 years of suffering. Then my life has improved every day since. My anxiety, depression, psychosis, and alcoholism is no more. I feel indebted to this drug as long as it keeps workin.

I haven’t missed a day of naltrexone since December 2015

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