Had to give up abilify after first day

Medications
41

Nvm read it. But whats the difference between partial agonists and full antagonists then?

42

If Caplyta is a partial dopamine agonist I’m really going to stay away from it.

43

What’s differential engagement in wikipedia Abilify?

44

you are like me.we tolerate the dopamine antagonists more than than agonists.

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45

I think he’s right if the article is right, Caplyta might be a partial agonist, Wikipedia just doesn’t say it.

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46

Not too sure, might want to do some research by googling or ask your doc on partial agonist Vs antagonist

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47

all of them partials agonists except a few older ones

48

Abilify, Rexulti, Vraylar and maybe Caplyta according to his article.

49

might be because we arabic we can only take antagonist ,heavier drugs

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50

Lol We’re humans just like others.

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51

I mean gentics im talking about genetics

52

I don’t think so, many north americans here on Clozapine which is the strongest. I am on a weaker med، Risperdal.

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53

Partial agonist is weaker than antagonist. Weird that I was more stable on Abilify than Latuda. Latuda is a full antagonist, Abilify is a partial agonist.

Agonist_2

54

ah ok i get ya i didnt know that.how strong do you think amulspride vs reperdiral

55

They are similar according to a meta study

56

According to Wikipedia amulspride is 10-15% stronger than Risperdal but it also depends on the dosage. I am on 4mg, max dosage is 8mg. You’re on 200mg amulspride, max dosage is 800mg.

57

That’s comparing agonist not antagonist
https://www.sciencedirect.com/science/article/abs/pii/S1472029906003845#:~:text=An%20agonist%20binds%20to%20the,receptor%20to%20a%20natural%20agonist.&text=Insurmountable%20antagonists%20bind%20strongly%20to,not%20reversed%20by%20additional%20agonist.

Here it says difference between antagonist and agonist

58

thanx for your help,answer.aziz seems to be busy.hes looking at the wickapedia lol

59

I know the difference lmao

“A key property of partial agonists is that they display both agonistic and antagonistic effects. In the presence of a full agonist , a partial agonist will act as an antagonist , competing with the full agonist for the same receptor and thereby reducing the ability of the full agonist to produce its maximum effect.”

https://link.springer.com/referenceworkentry/10.1007%2F978-3-540-68706-1_548#:~:text=A%20key%20property%20of%20partial,to%20produce%20its%20maximum%20effect.

60

Partial agonists can be antoagonists or agonists depending on dopamine concentration. I was right.
Dopamine (neurotransmitter) is a full agonist of the dopamine receptor.