# Gut Signature for Treatment-Resistant Schizophrenia?
A quote from the beginning:
Adults with resistant schizophrenia have significant gut microbiome differences compared with their counterparts who respond to treatment, a new finding that researchers speculate may be driven by treatment with clozapine.
Darryl Eyles, PhD, and colleagues with University of Queensland in Brisbane, Australia, believed this difference may be driven by clozapine-induced alterations in the gut, although the possibility that preexisting microbiome differences contribute to treatment resistance can’t be ruled out.
“Studies are needed to understand the clinical implications of our finding of an altered microbiome among people with treatment-resistant schizophrenia taking clozapine, specifically whether therapeutic strategies for treatment-resistant schizophrenia should consider microbiome adjuvants, including diet, physical activity, and probiotics,” they wrote.
The study was published online on January 31, 2024, in JAMA Psychiatry.