Early therapies focused solely on dopamine antagonism and second-generation antipsychotics focused on the dopamine and serotonin systems and their respective G protein coupled receptor (GPCR) proteins. Although debate for dimerization of certain classes of GPCR exist, the establishment of an mGlu2-5-HT2A heterocomplex, which is implicated in schizophrenia is of interest.
When studying the causal relationship between any chemical change and the sz condition.
A distinction must be made between two contradictory phenomena:
1-The change in the substances (D/S or G) precedes the sz condition and causes it
This is what all current theories suggest,and is not related to the realism of the sz condition.
the problem, there is no actual genetic cause for the chemical change
2-The independent functional activity of the pathogen in the conscious mind precedes the chemical change and causes it (qualitatively and quantitatively )
This is the reality of the sz condition,which differs about the content of all current theories
the pathogen itself which represented in the hallucination is the root cause for the chemical change
In other meaning,the independent functional activity of the pathogen in the conscious mind of the person generate the chemical change
What is the evidence ?
If the pathogen(hallucination) activity stop working (for any reasons) during the waking period,the sz condition and its existential symptoms will disappear during the stopping period,and the person will becomes in a chemical balance,and practices the rituals of his personal habits naturally without complaint
This will happen no matter how many hours the pathogen activity stops !
The correct observation:
Are the substances of chemical change gradually accumulating after each higher cognitive process?
OR,are the substances of change being secreted/not in one go (not increasing/decreasing with the passage of time or number of the mental processes ?