This is a really long article and much of it is devoted to cancer, but here is the part relevant to brain illnesses:
“We are particularly interested in synaptic integrity in the brain, which is a primary opportunity and challenge for the field of neuroscience,” says Adam J. Rosenberg, president and CEO of Rodin Therapeutics. “As part of this work, we continue to seek the validation of translational markers.” Synaptic loss of function or dysfunction drive symptoms in many neurodegenerative, neuropsychiatric, and neurodevelopmental conditions. To preserve or restore synaptic function—that is, to strengthen existing synapses and promote the creation of new synapses—Rodin focuses its drug discovery efforts on modulating neuronal gene expression.
Multiple biomarkers can be used to validate target engagement and functional efficacy. “We now have tools that were not available to us even two or three years ago,” notes Rosenberg. Rodin is positioning its drug development program to benefit patients with a range of conditions related to synaptic function. “As part of our disease-agnostic approach, we are initially focusing on neurodegeneration,” Rosenberg explains. “[We] hope to later enter other areas, including psychiatric conditions.”