With advances in sequencing and detection technology, genetic and epigenetic analyses can promote our comprehension of the pathogenesis of schizophrenia as well as the mechanisms underlying the negative symptoms and cognitive dysfunction in schizophrenia. Currently, the treatments of negative symptoms and cognitive dysfunction play key roles in the full recovery of patients with schizophrenia. The prospects for predominant negative symptoms are good, with the advent of new D3-selective dopamine antagonists such as cariprazine. Besides, some physical therapies have the potential to improve negative symptoms and cognitive dysfunction as well. Compared with other reviews on the negative symptoms [29, 104] or cognitive dysfunction in schizophrenia , in this review we report new advances in physical therapy as well as genetic and epigenetic mechanisms underlying these two symptoms.