Schizophrenia.com

Desipramine enhances the ability of paliperidone to decrease alcohol drinking

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Makes sense because Ne works against Da, but to get this effect, the Ne has to hit the targets (probably in the striatum, nucleus accumbens and ventral tegmentum) pretty much dead on without doing “collateral damage” to some other targets. Tricky, but very interesting.

(Wonder what George Koob will have to say, since he has been The Man on this sort of stuff for 25 years.)