COULD LOW α-N-ACETYLGALACTOSAMINIDASE PLASMA CONCENTRATION CAUSE Schizophrenia

Thank you, this is interesting. A quote from Wikipedia:

The human gene that codes for this enzyme is NAGA. Mutations in this gene and the deficiency in alpha-N-acetylgalactosaminidase activity have been identified as the cause of Schindler disease.

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However, in a different study dedicated to a different gene (NDUFA6) I found this:

Consistent with eQTL analysis, expression analysis showed that NAGA was significantly upregulated in brains of schizophrenia cases compared with controls, further supporting that rs1801311 may confer schizophrenia risk by regulating NAGA expression. Of note, we found that NAGA regulates important neurodevelopmental processes, including proliferation and differentiation of neural stem cells. Transcriptome analysis corroborated that NAGA regulates pathways associated with neuronal differentiation.

( A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression, 2021)

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